Functional Self-organized Cardiac and Skeletal Muscle Engineered in vitro
- pdf version of the abstract

Abstract:
Under the proper conditions in cell culture, skeletal muscle and cardiac myocytes can be guided to self-organize into functional, 3-dimensional cylindrical tissue constructs. These constructs do not include a pre-existing scaffold to define the size and shape of the resulting tissue. They can be used to study the formation and phenotypic development of functional contractile muscle tissues, the formation of tissue-to-tissue interfaces (such as muscle-tendon), and the effects of both electrical and mechanical stimulation on tissue development and maturation.

Brief CV:
Bob Dennis, Ph.D.
B.S.E Mechanical Engineering, University of Michigan
Ph.D. Biomedical Engineering, University of Michigan

Academic Appointments & Affiliations:
Assistant Professor of Mechanical Engineering, University of Michigan
Assistant Professor of Biomedical Engineering, University of Michigan
Assistant Professor of Surgery (Plastic & Reconstructive), University of Michigan
Assistant Research Scientist, Institute of Gerontology, University of Michigan
Visiting Research Scientist, MIT Artificial Intelligence Laboratory
Visiting Research Scientist, Harvard-MIT Health Sciences and Technology Program