A BioAssembly Tool (BAT) for Regenerative Medicine
- pdf version of the abstract

Abstract: This seminar will describe the design and fabrication of surface modified biomaterials and tissue engineered constructs using a direct write printing system. We define this system as a BioAssembly Tool (BAT) as it provides the capability to generate spatially organized constructs utilizing three-dimensional printing to co-extrude cells and biomaterials. A unique component of our design and fabrication capabilities is the ability to construct engineered cardiovascular tissue for revascularization of ischemic tissue. The cellular composition of the tissue engineered constructs can be controlled through layer-by-layer extrusion of cells and matrix materials as well as through porosity and permeability of the scaffold. The BioAssembly Tool provides a device capable of surface modifying biomaterials and creating three-dimensional structures. Cardiovascular constructs have been fabricated and evaluated using in vitro differentiation analysis. Vascular endothelial cells and muscle cells remain viable after construct fabrication and exhibit the ability to undergo differentiation. Three dimensional construction of pre-vascularized tissue has been achieved using the BioAssembly Tool.

Monday, October 20, 2003
1:30 p.m.
Arizona Health Sciences Center, Room 5403
Host: Urs Utzinger, Ph.D. (626-9281)