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Biomedical Engineering Seminar
Abstract
Fall 2005, September 12,
John Szivek, Ph. D.,Radiation Oncology, University of Arizona
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"Sensate Scaffold Development: Adventures in Tissue Engineering
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Abstract: Currently, no technique available for the treatment
of large focal cartilage defects produces consistently good results. In
particular, large defects and defects in older patients have
not healed well after available cartilage transplant and cell
seeding techniques were utilized. This has led researchers
to study the use of scaffolds on which cartilage tissue can be
grown prior to implanting it into the joint.
This talk will focus on a scaffold system being developed in the
Orthopaedic Research Lab which will provide a supporting surface
for engineered cartilage tissue. Developments to date have
included methods for production of scaffolds with simple and complex
internal geometries using a rapid prototyping technique, development
of a TCP coating technique to encourage rapid bone ingrowth and
fixation of the scaffold in bone, development of methods for attaching
sensors to the scaffold to measure load while it is in place in
the knee joint and development of techniques to grow cartilage
tissue while being loaded to load levels measured in joints.
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