Biomedical Engineering Seminar
Abstract
Spring 2006, Feb 13, Irving J. Bigio, Professor,
Departments of Biomedical Engineering, Electrical & Computer
Engineering, and Physics, Boston University
|
"Elastic scattering
spectroscopy for noninvasive detection of cancer"
-pdf
Abstract: Optical spectroscopy mediated by fibre-optic probes
can be used to perform noninvasive, or minimally-invasive, real-time
assessment of tissue pathology in-situ. The most
common approach has been based on UV-induced fluorescence spectroscopy,
although Raman spectroscopy has also been investigated. These
methods are responsive to biomolecular/biochemical changes in
cells. On the other hand, the method of elastic-scattering
spectroscopy (ESS) is sensitive to the sub-cellular architectural
changes, such as nuclear grade or nuclear to cytoplasm ratio,
mitochondrial size and density, etc., which correlate with features
used in histological assessment. The ESS method senses
those morphology changes in a semi-quantitative manner, without
actually imaging the microscopic structure.
Clinical demonstrations of ESS have been conducted for organs sites
that are endoscope-accessible or directly-accessible. Promising
results have been obtained in the areas of breast cancer, esophageal
cancer, colon cancer, skin cancer, oral cancer, and other organ
sites. Larger-scale clinical studies are now starti
|
