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Arizona Health Sciences Center, Room 8401
David Margolis
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Assistant Professor, Orthopaedic Surgery
Degrees
- M.D. Medicine
- The University of Arizona, Tucson, Arizona, United States
- Ph.D. Physiological Sciences
- The University of Arizona, Tucson, Arizona, United States
- Bone Phenotype of Carbonic Anhydrase II Deficient and Calbindin-D28k Knockout Mice and Development of a Method to Measure In Vivo Bone Strains in Mice
- M.S. Physiological Sciences
- The University of Arizona, Tucson, Arizona, United States
- Bone Remodeling in Calbindin-D28k Knockout Mice
- B.S. Chemistry
- The University of Arizona, Tucson, Arizona, United States
Courses
Honors Independent Study
BME 299H (Fall 2023)
BME 299H (Spring 2023)
BME 299H (Spring 2021)
HNRS 399H (Spring 2024)
PSIO 399H (Spring 2024)
PSIO 399H (Fall 2023)
Directed Research
BME 492 (Spring 2024)
BME 492 (Fall 2023)
BME 492 (Spring 2023)
BME 492 (Fall 2022)
BME 492 (Summer I 2022)
BME 492 (Spring 2022)
BME 492 (Fall 2020)
BME 492 (Spring 2020)
BME 492 (Spring 2019)
BSM 492 (Spring 2024)
NSCS 392 (Spring 2023)
NSCS 392 (Fall 2022)
PSIO 492 (Spring 2024)
PSIO 492 (Fall 2023)
PSIO 492 (Spring 2023)
PSIO 492 (Fall 2022)
Honors Directed Research
BIOC 392H (Spring 2023)
BIOC 392H (Fall 2022)
Independent Study
PSIO 399 (Spring 2024)
PSIO 399 (Fall 2023)
PSIO 499 (Spring 2024)
PSIO 499 (Fall 2023)
Honors Thesis
BIOC 498H (Spring 2024)
BIOC 498H (Fall 2023)
ECOL 498H (Spring 2024)
ECOL 498H (Fall 2023)
PSIO 498H (Spring 2022)
PSIO 498H (Fall 2021)
PSIO 498H (Spring 2020)
PSIO 498H (Fall 2019)
Rsrch Meth Biomed Engr
BME 592 (Fall 2021)
Gen Orthopaedic Elect II
ORTH 880B (Spring 2024)
ORTH 880B (Spring 2021)
Thesis
CMM 910 (Summer I 2021)
CMM 910 (Spring 2021)
CMM 910 (Fall 2020)
Dissertation
BME 920 (Fall 2024)
BME 920 (Spring 2024)
BME 920 (Fall 2023)
BME 920 (Spring 2023)
BME 920 (Spring 2022)
Licensure & Certification
- Arizona Medical License, Arizona Medical Board (2016)
- Massacchusetts Medical License, Board of Registration in Medicine (2015)
Selected Publications
Journals/Publications
- Margolis, D. S. (2023).
Robot and ultrasound assisted needle insertion to the transverse carpal ligament.
. Clinical Biomechanics, 101. doi:10.1016/j.clinbiomech.2022.105851
- Margolis, D. S. (2023). Morphine-induced osteolysis and hypersensitivity is mediated via TLR4 in a murine model of metastatic breast cancer.. Pain, 164(11), 2463-2476. doi:10.1097/j.pain.0000000000002953
- Margolis, D. S. (2021). A Large Segmental Mid-diaphyseal Femoral Defect Sheep Model: Surgical Technique. Journal of Investigative Surgery.
- Margolis, D. S. (2022). Dose- and time-dependent effects of collagenase clostridium histolyticum injection on traverse carpal ligament elastic modulus and thickness in vitro. PLOS ONE, 17(12). doi:10.1371/journal.pone.0277187
- Margolis, D. S. (2022). A large Mid-Diaphyseal Femoral Defect Sheep Model: Surgical Technique. Journal of Investigative Surgery, 35(6), 1287-1295. doi:doi: 10.1080/08941939.2022.2045393
- Margolis, D. S., Hawk, J., Daulat, S., & Li, Z. (2022). Dose- and time-dependent effects of collagenase clostridium histolyticum injection on transverse carpal ligament elastic modulus and thickness in vitro. https://doi.org/10.1371/journal.pone.0277187. PLOS ONE.
- Margolis, D. S. (2021). Osseosurface electronics – wireless, fully-implantable electronics grown on the bone. Nature Communications.
- Margolis, D. S. (2016). Predicting Vancouver types B1 and B2 periprosthetic fractures of the femur.. University of New Mexico Orthpaedics Research Journal, 5, 36-39.
- Margolis, D. S., Bennett, D. M., Koehler, L. R., Radelet, M. J., Lu, Z., Pedri, T. G., Decker, M. M., & Miller, M. D. (2016). Predicting Vancouver types B1 and B2 periprosthetic fractures of the femur.. University of New Mexico Orthopaedics Research Journal, 5, 36-39.
- Matthews, J. R., Margolis, D. S., Wu, E., & Truchan, L. M. (2015). Brachial Plexopathy Following Use of Recombinant Human BMP-2 for Treatment of Atrophic Delayed Union of the Clavicle. JBJS case connector, 5(3), e81-e5.
- Thai, J. N., Pacheco, J. A., Margolis, D. S., Swartz, T., Massey, B. Z., Guisto, J. A., Smith, J. L., & Sheppard, J. E. (2015). Evidence-based Comprehensive Approach to Forearm Arterial Laceration. The western journal of emergency medicine, 16(7), 1127-34.
- Margolis, D. S., Wu, E. W., & Truchan, L. M. (2013). Axonal loss in murine peripheral nerves following exposure to recombinant human bone morphogenetic protein-2 in an absorbable collagen sponge. The Journal of bone and joint surgery. American volume, 95(7), 611-9.
- Wild, J. R., Askam, B. M., Margolis, D. S., Geffre, C. P., Krupinski, E. A., & Truchan, L. M. (2012). Biomechanical evaluation of suture-augmented locking plate fixation for proximal third fractures of the olecranon. Journal of orthopaedic trauma, 26(9), 533-8.
- Geffre, C. P., Finkbone, P. R., Bliss, C. L., Margolis, D. S., & Szivek, J. A. (2010). Load measurement accuracy from sensate scaffolds with and without a cartilage surface. Journal of investigative surgery : the official journal of the Academy of Surgical Research, 23(3), 156-62.
- Geffre, C. P., Ochoa, J., Margolis, D. S., & Szivek, J. A. (2010). Evaluation of the osteogenic performance of calcium phosphate-chitosan bone fillers. Journal of investigative surgery : the official journal of the Academy of Surgical Research, 23(3), 134-41.
Poster Presentations
- Margolis, D. S. (2022, February). In Situ Needle Insertion to the Transverse Carpal Ligament Using Robot-assisted Ultrasound. ORS Annual Meeting. Tampa, Florida: ORS.
- Margolis, D. S. (2022, February). Mechanical Testing and Histological Analysis of Bone Growth into Bioresorbable Porous 3D Composite Scaffolds. ORS Annual Meeting. Tampa, Florida: ORS.
- Margolis, D. S. (2022, January). Bone Ingrown Dynamized Long Bone Segment Regeneration Scaffolds Successfully Support Full Body Weight within 9 Months. Society for Biomaterials Combined Meeting. Honolulu HI: Society for Biomaterials Combined Meeting.
- Margolis, D. S. (2022, January). Quantitative CT Analysis and Mechanical Coupling of Implanted Bioresorbable Composite Scaffolds to Bone (see attached). Society for Biomaterials Combined Meeting (Jan 7-10, 2022)Society for Biomaterials Combined Meeting.
- Margolis, D. S. (2022, January). Quantitative CT Analysis and Mechanical Coupling of Implanted Bioresorbable Composite Scaffolds to Bone. Society for Biomaterials Combined MeetingSociety for Biomaterials Combined Meeting.
- Margolis, D. S. (2020, Feb 2020). Peer Refereed Abstract: Large Defect Scaffolds Show Loading Changes After Bone Regeneration, Dynamization and Rod Removal. Orthopaedic Research Society Annual MeetingORS.
- Margolis, D. S. (2020, Feb 2020). Peer Refereed Abstract: Osteoconductive Biomimetic Polymer Ceramic Composite Scaffolds for Bone Tissue Regeneration. ORS Annual Meeting. Phoenix, AZ: ORS.
- Margolis, D. S. (2020, Feb 2020). Resorbable Polymer Ceramic Composite Biomimetic Scaffolds Support Osteoblastic Differentiation of Stem Cells.. ORS Annual Meeting. Phoenix, AZ: ORS.
- Margolis, D. S. (2020, Feb). Large Defect Scaffolds Show Loading Changes After Bone Regeneration, Dynamization and Rod Removal. Annual ORS Meeting. Phoenix, Arizona.
- Margolis, D. S. (2020, Feb). Osteoconductive Biomimetic Polymer Ceramic Composite Scaffolds for Bone Tissue Regeneration. Annual ORS Meeting. Phoenix, Arizona: ORS.
- Margolis, D. S. (2020, Feb). Polymer Ceramic Hybrid Scaffolds for Bone Tissue Regeneration. Annual ORS Meeting. Phoenix, Arizona: ORS.
- Margolis, D. S. (2020, Feb). Poster Presentation: Large Defect Scaffolds Show Loading Changes After Bone Regeneration, Dynamization And Rod Removal. ORS Annual Meeting, Feb 8-11, 2020. Phoenix: ORS.
- Margolis, D. S. (2020, Feb). Poster Presentation: Osteoconductive Biomimetic Polymer Ceramic Composite Scaffolds For Bone Tissue Regeneration. ORS Annual Meeting, Feb 8-11, 2020. Phoenix: ORS.
- Margolis, D. S. (2020, Feb). Poster Presentation: Resorbable Polymer Ceramic Composite Biomimetic Scaffolds Support Osteoblastic Differentiation Of Stem Cells. ORS Annual Meeting, Feb 8-11, 2020. Phoenix: ORS.
- Margolis, D. S. (2020, Feb). Resorbable Polymer Ceramic Composite Biomimetic Scaffolds Support Osteoblastic Differentiation of Stem Cells. Annual ORS Meeting. Phoenix, Arizona: ORS.
Presentations
- Margolis, D. S. (2023).
Local/Regional Conferences/Presentations
1. Childers R, Romero AN, Figueroa G, Gonzales DA, Arciniaga LF, Loy DA, Muralidharan K, Potter BG, Szivek JA, Margolis DS. The Effect of Biomimetic Composite Scaffolds on Osteogenesis In Vivo. Poster Presentation. Mayo Clinic Symposium on Regenerative Medicine and Surgery. Scottsdale, Arizona, April 2023
National Conferences/Presentations
1. Childers R, Romero AN, Figueroa G, Gonzales DA, Arciniaga LF, Loy DA, Muralidharan K, Potter BG, Szivek JA, Margolis DS. Histology and Histomorphometry of Bone Regenerating Composite Polymer Ceramic Scaffolds in a Rat Model. Poster Presentation. Orthopaedic Research Society. Dallas, Texas, February 2023.
2. Margolis DS, Figueroa G, Gonzales DA, Szivek JA. Biomimetic Sensate 3D Printed Scaffolds Support Rapid Bone Regeneration and Full Weight Bearing for 2 Years in a Large Segmental Femoral Defect Model in Sheep. Poster Presentation. Orthopaedic Research Society. Dallas, Texas, February 2023.
3. Maldonado SR, Figueroa G, Gonzalez DA, Margolis DS. Testing of Different Hydroxyapatite Particles in Cell Culture. Poster Presentation. Society of Biomaterials, San Diego, California, April 2023.
4. Figueroa G, Gonzales DA, Szivek JA, Margolis DS. Dynamization Increases Bone Stiffness in Regenerated Bone with Polymer Scaffolds. Poster Presentation. Society of Biomaterials, San Diego, California, April 2023.
5. Childers R, Romero AN, Figueroa G, Gonzales DA, Arciniaga LF, Loy DA, Muralidharan K, Potter BG, Szivek JA, Margolis DS. The Future of Bone Regeneration: Histological Analysis of Biomimetic Composite Scaffolds in a Rat Model. Medical Student Orthopedic Society. Virtual Conference, April 2023.
6. Irby M, Froio J, Petit-Miller A, Gonzales DA, Figueroa G, Margolis DS. The Response of Human Osteoblasts to Biaxial Biomimetic Patterns of Load. Medical Student Orthopedic Society. Virtual Conference, April 2023.
7. Hawk J, Margolis DS, Li ZM. Transverse Carpal Ligament Elongation after Injection of Collagenase In Situ. Poster Presentation. Summer Biomechanics, Bioengineering and Biotransport Conference, Vail, Colorado, June 2023.
8. Margolis DS, Gonzales DA, Figueroa G, Smith J, Szivek JA. Large Segmental Bone Defects in Sheep Treated with 3D Printed Scaffolds and Autologous Adipose Derived Stem Cells Demonstrate Increased Stiffness Following Hardware Removal. Poster Presentation. Military Health System Research Symposium, Kissimmee, Florida. August 2023.
. See attached. - Margolis, D. S. (2022). See attached list of 2022 presentations x 6. See attached list of 2022 presentations x 6.
- Margolis, D. S. (2019, Feb). Research Day Data Blitz (presentations x 4). Research Day Data Blitz (February 13, 2019). UA College of Medicine: UA.
- Margolis, D. S. (2019, Jan). Patient Specific Scaffolds for Treatment of Scaphoid Fractures and Nonunions with Significant Bone Loss. Auual AAHS meeting. Palm Desert, California: AAHS.
- Margolis, D. S. (2017, June). Development and Testing of a Long Bone Segment Regenerating Scaffold for Patients.. Summer Biomechanics, Bioengineering and Biotransport Conference.. Tucson, Arizona: SB3C.
- Margolis, D. S. (2019, Jan). Patient Specific Scaffolds for Treatment of Scaphoid Fractures and Nonunions with Significant Bone Loss. Auual AAHS meeting. Palm Desert, California: AAHS.
Awards
- Bear-Down Award
- The University of Arizona, Fall 1997
- Arizona Medical Association Volunteer Preceptorship Award ($1,000)
- American Medical Association, Fall 2023
- Fellow of the AAOS
- AAOS, Fall 2021
- Candidate Member to become a fellow in the AAOS
- AAOS, Summer I 2016
- AOA Resident Leadership Nominee
- The University of Arizona, Department of Orthopaedic Surgery, Fall 2014
- Chariman's Award
- The University of Arizona, Department of Orthopaedic Surgery, Fall 2013
- Excellence in Research Award
- The University of Arizona, College of Medicine, Fall 2010
- Honors in Research
- The Medical Student Research Program, The University of Arizona, Fall 2010
- Van Winkle Award for Excellence in Surgical Research
- The University of Arizona, Spring 2008
- TRIF Fellow
- The University of Arizona, Fall 2007
- ASUA Academic Enrichment Grant
- Associated Students of The University of Arizona, Spring 2007
- Hear, Lung and Blood Fellow
- The University of Arizona, Fall 2005
- Up-and-Comers Under 25 in Tucson
- Arizona Daily Star, Fall 2005
- SWAIR Imaging Fellow
- The University of Arizona, Fall 2003