University of Arizona Biomedical Engineering  
Angiogenesis and the Extracellular Matrix
In vitro Tissue Model for Optical Imaging of Ovary  
Optical imaging as Biomarker to study the Modulation Ovarian Cancer using Fenretinide and Oral Contraceptives  
Comprehensive Program for Early Detection of
Female Genital Tract Abnormalities
Optimized Visual Examination of Cancer  
Public Data  
Lab Pictures  

Laboratory in Tissue Spectroscopy and Bio-Signatures



Kirkpatrick ND, Zou C, Brewer MA, Brands WR, Drezek RA, Utzinger U, Endogenous fluorescence spectroscopy of cell suspensions for chemopreventive drug monitoring. Photochemistry and Photobiology, 81:125-134, 2005.


Wang A, Bender J, Pfefer JT, Utzinger U, Drezek RA, Depth sensitive reflectance measurements using obliquely oriented fiber probes. Journal of Biomedical Optics, submitted, 2004.

Brewer MA, Utzinger U, Barton JK, Hoying JB, Kirkpatrick ND, Brands WR, Davis JR, Hunt K, Stevens SJ, Gmitro AF, Imaging of the Ovary. Technology in Cancer Research & Treatment, 3(6): 617-627, December 2004.

Tumlinson AR, Hariri LP, Utzinger U, Barton JK, Miniature endoscope for simultaneous optical coherence tomography and laser-induced fluorescence measurements. Applied Optics 43(1):113-121, 2004.


Utzinger U, Bueeler M, Oh, S, Heintzelman DL, Svistun ES, Abd-El-Barr M, Gillenwater A, Richards-Kortum R, Optimal Visual Perception and Detection of Oral Cavity Neoplasia, submitted, IEEE Transactions on Biomedical Engineering 50(3): 396-399, 2003.

Brookner C, Utzinger U, Follen M, Richards-Kortum R, Cox D, Atkinson EN, Effects of biographical variables on cervical fluorescence emission spectra, Journal of Biomedical Optics 8(3): 479483, July 2003
Chang SK, Dawood Y, Staerkel G, Utzinger U, Richards-Kortum R, Follen M, Fluorescence spectroscopy for Cervical Pre-Cancer Detection: Is There Variance Across the Menstrual Cycle?, submitted, Journal of Biomedical Optics, 2002.
Chang S, Follen M, Malpica A, Utzinger U, Staerkel G, Cox D, Atkinson EN,
MacAulay C, and Richards-Kortum R, Optimal Excitation Wavelengths for Discrimination of Cervical Neoplasia, IEEE Transactions on Biomedical Engineering, 49(10): 1102-110, 2002.
MacAulay C, Richards-Kortum R, Fedyk A, Atkinson EN, Cox D, Follen M, Utzinger U, Variation of fluorescence spectroscopy during the menstrual cycle, Optics Express, 10(12):493-504, 2002.
Cox D, Chang SK, Dawood MY, Staerkel G, Utzinger U, Richards-Kortum R, Follen M, Detecting the Signal of the Menstrual Cycle in Fluorescence Spectroscopy of the Cervix, submitted, Applied spectroscopy, 2001.
Myakov A, Wicky L, Savchenko N, Utzinger U, Richards-Kortum R, Sokolov K, Fiber optic probe for polarized reflectance spectroscopy in vivo: design and performance, submitted, Journal of Biomedical Optics, 2001.
Brewer M, Utzinger U, Li Y, Atkinson N, Satterfield W, Richards-Kortum R, Follen M, Bast RC, Fluorescence Spectroscopy as a Biomarker in a Cell Culture and in a Non-Human Rhesus Primate Model for Ovarian Cancer Chemopreventive Agents, in press, Journal of Biomedical Optics, 2001.
Brewer M, Baze W, Hill H, Utzinger U, Wharton JT, Follen M, Khan-Dawood F, Satterfield W, Non-Human Primate Model for Ovarian Cancer Chemoprevention, submitted, Laboratory Animal Sciences, 2001.
Utzinger U, Richards-Kortum R, Fiberoptic probes for optical spectroscopy, review article, accepted, Journal of Biomedical Optics, 2001.
Drezek R, Sokolov K, Utzinger U, Boiko I, Malpica A, Follen M, Richards-Kortum R, Understanding the contributions of NADH and Collagen to cervical tissue fluorescence spectra: modeling, measurements and implications, Journal of Biomedical Optics, 6:385-96, 2001.
Utzinger U, Heintzelman DL, Mahadevan-Jansen A, Malpica A, Follen M, Richards-Kortum R, Near infrared Raman spectroscopy for in vivo detection of cervical precancers, Applied Spectroscopy, 55(8):955-959, 2001.
Brewer M, Utzinger U, Silva E, Gershenson D, Bast RC, Follen M, Richards-Kortum R, Fluorescence spectroscopy for in vivo characterization of ovarian tissue, in press, Lasers in Surgery and Medicine, 28, 2001.
Coghlan L, Utzinger U, Richards-Kortum R, Brookner C, Zuluaga A, Gimenez-Conti I, Follen M, Fluorescence spectroscopy of epithelial tissue throughout the dysplasia-carcinoma sequence in an animal model: spectroscopic changes precede morphologic changes, Lasers in Surgery and Medicine, 29:1-10,2001.
Brewer M, Utzinger U, Satterfield W, Hill L, Gershenson D, Bast RC, Wharton JT, Richards-Kortum R, Follen M, Biomarker modulation in a non-human rhesus primate model for ovarian cancer chemoprevention, Cancer Epidemiology Biomarkers and Prevention, 10:889-893, 2001.
Utzinger U, Brewer M, Silva E, Gershenson D, Bast RC, Follen M, Richards-Kortum R, Reflectance spectroscopy for in vivo characterization of ovarian tissue, Lasers in Surgery and Medicine, 28:56-66, 2001.
Coghlan L, Utzinger U, Drezek U, Heintzelman DL, Zuluaga A, Brookner C, Richards-Kortum, Gimenez-Conti I, Follen M, Optimal fluorescence excitation wavelengths for detection of squamous intra-epithelial neoplasia: results from an animal model, Optics Express 7(12):436-446, 2000. Video
Heintzelman DL, Utzinger U, Fuchs H, Zuluaga A, Gossage K, Gillenwater A, Jacob R, Kemp B, Richards-Kortum R; Optimal excitation wavelengths for in vivo detection of oral neoplasia using fluorescence spectroscopy, Photochemistry and Photobiology 72(1):103-113, 2000.
Utzinger U, Trujillo EV, Atkinson EN, Follen-Mitchell M, Cantor SB, Richards-Kortum R, Performance estimation of diagnostic tests for cervical pre-cancer based on fluorescence spectroscopy: effects of tissue type, sample size, population and signal to noise ratio, IEEE Transactions on Biomedical Engineering, 46(11):1293-303, 1999.
Mitchell MF, Cantor SB, Brookner C, Utzinger U, Schottenfeld D, Richards-Kortum R, Screening for squamous intraepithelial lesions with fluorescence spectroscopy. Obstetrics & Gynecology. 94(5 Pt 2):889-96, 1999.
Agrawal A, Utzinger U, Brookner C, Pitris C, Mitchell MF, Richards-Kortum R, Fluorescence spectroscopy of the cervix: influence of acetic acid, cervical mucus, and vaginal medications, Lasers in Surgery & Medicine 25(3):237-49, 1999.
Brookner CK, Utzinger U, Staerkel G, Richards-Kortum R, Mitchell MF, Cervical fluorescence of normal women. Lasers in Surgery & Medicine. 24(1):29-37, 1999.
Zuluaga A, Utzinger U, Durkin T, Fuchs H, Gillenwater A, Richards-Kortum R, Fluorescence excitation emission matrices of human tissue: a system for in vivo measurement and method of data analysis, Applied Spectroscopy, 53(3):302-311, 1999.
Mahadevan-Jansen A, Follen Mitchell M, Ramanujam N, Utzinger U, Richards-Kortum R; Development of a fiber optic probe to measure NIR Raman spectra of cervical tissue in vivo, Photochemistry and Photobiology, 68(3):427-31, 1998.
Mahadevan-Jansen A, Follen Mitchell M, Ramanujam N, Malpica A, Thomsen S, Utzinger U, Richards-Kortum R; Near-infrared Raman spectroscopy for detection of cervical precancers, Photochemistry and Photobiology, 68(1):123-32, 1998.
Trujillo EV, Sandison DR, Utzinger U, Ramanujam N, Follen-Mitchell M, Richards-Kortum R, A method to determine tissue fluorescence efficiency in vivo and predict signal to noise ratio for spectrometers, Applied Spectroscopy, 52 (7): 943-951, 1998.
[5] Strebel RT, Utzinger U, Peltola M, Schneider J, Niederer PF, Hess OM, Excimer laser spectroscopy: influence of tissue ablation on vessel wall fluorescence, Journal of Laser Applications, 10(1): 34-40, 1998.
[4] Mayer IV, Lazarov MP, Utzinger U, Freiburghaus AU, Hess OM, Sonicated X-ray contrast agents for quantitative myocardial contrast echocardiography - a critical approach, Heart & Vessels, 10(2): 96-105, 1995.
[3] Kaufmann P, Vassalli G, Utzinger U, Hess OM, Coronary vasomotion during dynamic exercise: influence of intravenous and intracoronary nicardipine, Journal of the American College of Cardiology, 26(3): 624-31, 1995.
[2] Bosshart F, Utzinger U, Hess OM, Wyser J, Mueller A, Schneider J, Niederer P, Anliker M, Krayenbuehl HP, Fluorescence Spectroscopy for identification of atherosclerotic tissue, Cardiovascular Research, 26(6): 620-5, 1992.
[1] Dillier N, Senn C, Schlatter T, Stockli M, Utzinger U, Wearable digital speech processor for cochlear implants using a TMS320C25, Acta Oto-Laryngologica - Suppl., 469: 120-7, 1990.


Book Chapters
[2] Richards-Kortum R, Drezek R, Basen-Engquist K, Cantor S, Utzinger U, Brookner C, Follen M. "Chapter 9: Cervical Dysplasia Diagnosis with Fluorescence Spectroscopy. Handbook of Biomedical Fluroescence, edited by Brian Pogue, PhD, and Mary Ann Mycek, PhD. Marcel Deckker: New York, NY, 2003.

[1] Utzinger U, Richards-Kortum R, Fundamentals of spectroscopy: fiber optic probes, Encyclopedia of spectroscopy and spectrometry, ed John Lindon, George Tranter, John Holmes, Academic Press Ltd., 1999.