Utzingerís research focuses on the development
of optical techniques for the early diagnosis
of tissue pathologies and monitoring of drug
In our clinically oriented
research we use a collaborative and interdisciplinary
approach to investigate optical tools for
the evaluation of female genital tract abnormalities.
Currently, the research emphasis includes
the application of spectroscopic techniques
in microscopic and macroscopic imaging of
tissue in-vivo and in culture.
To understand the biology
of extracellular matrix degradation
we investigate the optical signature of the
collagen matrix in a cultured environment
with spectrofluorimetry and multiphoton microscopy.
In particular the effects of angiogenesis
and collagenase are studied.
In a collaborative project
on imaging the mouse colon,
we develop a miniaturized fiberoptic imaging
system and novel tomographic and spectroscopic
data analysis and management tools.
We investigate optical signatures
of endogenous tissue constituents for its
diagnostic and prognostic potential. We also
evaluate those signatures to determine their
role as confining factors for novel molecular
imaging techniques. Signatures are obtained
in a clinical setting in situ or in vitro
from tissue and arganotypic cultures as well
as cell and matrix models. Data is linked
through mathematical models with metabolism,
oxygenation, matrix integrity and morphology.
The research groupís vision
is to develop new technologies for tissue
assessment that will increase performance
of diagnosis and prognosis, that are cost-effective,
and that will increase access to health care.
To achieve this goal the laboratory
- designs and tests custom imaging and
spectroscopy devices for the clinic,
- develops multispectral microscopy techniques,
- creates biophysical models for optical
data analyses and
- develops tissue, cell and matrix models.
Ovarian Access to Transvaginal Aspiration
of Follicles. (Video 1.5